“I feel it in my fingers, I feel it in my toes, the love that is all around me.” These might be the words of a popular Christmas song from the movie Love Actually, but this could just as easily be a song about macromolecules—large molecules all around us. From your nails and hair to the rubber tips on your earphones, they are everywhere. You are made of macromolecules and so are trees and plastic water bottles! We call them polymers—long stretches of identical molecules with a range of useful properties, like toughness or stretchiness. And, it turns out, we just cannot live without them. Polymers occur both naturally—the DNA in our cells is a polymer—and synthetically (man-made), like plastic, Silly Putty and Styrofoam. This article uncovers the mysteries of polymers and explains how these fascinating materials have shaped life as we know it.
Macromolecular Materials—Building Blocks of Life
The scientific word for a very large molecule is macromolecule, because “macro” means large. Polymers are macromolecular materials that touch almost every aspect of our lives. Chances are most of us have been in contact with at least one polymer-containing product—from water bottles to gadgets to tires—in the last 5 min. In fact, the term polymer itself gives us a clue about how these materials are designed. In Greek, “poly” means many, and “mer” means part. To better picture this, imagine you are making a necklace out of beads. Each bead represents an atom. You could string together single beads in a row. Or, you could make clusters of one type of bead with other ones, and then string those together. In a polymer, the individual beads are called monomers. Once put together, the monomers make up the polymer. Figure 1 shows a simplified diagram of how monomers build different types of polymers.
To better understand polymers, we must examine each type of monomer they are made from. Polymers come in different shapes and sizes, and they are either man-made or naturally occurring in plants or animals. For example, proteins are one type of polymer and they are made from monomers called amino acids. Depending on which amino acids and how many of them bond together, the resulting protein could be found in hair or nails, muscles, skin, or important cell machinery. Another naturally occurring polymer is starch, which serves as the food storage for plants like potatoes, corn, and wheat. Starch is a tasty polymer that can be found in bread and pasta! For the past 150 years, humans have been learning how to make synthetic (or man-made) polymers. Today, we can play with natural polymers like cellulose—a polymer made out of glucose (a form of sugar)—or human-made polymers like Teflon, which is derived from petroleum oil.
The Story of Macromolecules
Although polymers may be as old as life itself, we have only known about them since the 1830s when scientists first described them. The first synthetic polymer, known as Bakelite, which was the first plastic, was made in 1907 by an easy and inexpensive reaction. Later, Bakelite helped engineers to manufacture many types of children’s toys and kitchenware. But it was not until the 1920s when Herman Staudinger, a German scientist who worked on these synthetic polymers, coined the term macromolecule. Unfortunately, many scientists did not believe him about the existence of macromolecules because, at the time, a lot of chemists were reluctant to admit the existence of “giant organic molecules.” Rather, they preferred the idea that many natural substances—such as cellulose, silk, and rubber—consisted of small units held together by exceptionally strong forces. After Staudinger announced the concept of macromolecules, one well-known chemist even said, “you might as well claim that somewhere in Africa one elephant was found who was 1,500 feet long and 300 feet high” [1, 2]. Funnily enough, while the elephant did not exist, the polymer did, and the discovery of polymers revolutionized science.
It was not until the 1940–50s when researchers discovered that some polymers existed naturally in the human body, including proteins, which we already described as polymers of amino acid monomers, and DNA. DNA is made of monomers called nucleotides. When scientists built the first model of the natural polymer DNA, they realized that the structure of the DNA molecule helped to explain the way DNA functions to code for all the information needed to create the organism.
The Structure of Macromolecules
As time went on, scientists continued to study the structure of macromolecules. They found that natural polymers are often much smaller than their longer synthetic versions. They also discovered that the length of these synthetic polymers, and the patterns in which the monomers are arranged, are what makes synthetic polymers strong, lightweight, transparent, and flexible. But polymers also have another superpower—they have many different shapes! In Figure 2A, you can see three main shapes of polymers: linear, branched, and cross-linked. Long, linear polymers look like cooked spaghetti. Unlike branched polymers, linear polymers are likely to get tangled up and become sticky and elastic. On the other hand, cross-linked polymers have lots of branching, so the polymer chains cannot move past each other. It is this property that makes them hard, rigid, and brittle, and thus useful in crafting hard materials, such as the cross-linked rubber (styrene-butadiene rubber) that is used for most car and truck tires. The crosslinked polymer structure is why rubber car tires do not melt when you drive very fast, even though they get very hot from friction with the road.
Since we learned how to create and work with them, polymers, such as polyamide, polyester, and polyethylene have saturated our world. Polyamides are as strong as the bulletproof materials they are used for—like bulletproof vests. However, polyesters contain weaker bonds, and we use them to make things like biodegradable stitches for sewing up wounds. You can see some other polymer structures in Figure 2B, including some of the more complicated natural polymers made from sugars, amino acids, and nucleotides.
Why Are Macromolecules Important for Our Health?
Macromolecules have some pretty serious roles to play in the everyday functioning of our cells. For example, when synthetic polymers, which are used in implants for broken bones or in medicines, interact with our bodies, we need to make sure that they do not stay inside us for too long, because they can build up to toxic levels and become dangerous to body’s health! So, these synthetic polymers are designed such that after they accomplish their tasks, they break down into smaller parts that our cells can naturally process. Due to their degradation within our bodies, we call these biodegradable polymers. One example of a class of biodegradable polymers are polyesters that are utilized in countless biomedical applications, such as dissolvable stiches, and also screws, plates, and pins, to support the repair of broken bones and hold them together. It is also important that synthetic polymers be compatible with our bodies, which is called biocompatibility. Biocompatibility allows the body to function normally in the presence of the polymer, without having any allergic reactions or adverse side effects from the polymer.
It is clear that the use of polymers has impacted our health, sometimes without us even knowing about it . Here is an example. When we are sick, we usually have to swallow pills to help us get better more quickly. These pills generally dissolve in the stomach so that the medicine gets into the bloodstream. But, unfortunately, sometimes the drug is destroyed in the stomach or intestine before it gets into the blood stream and reaches the unhealthy organ. Or sometimes, the medicine does not have a chance to dissolve in the stomach. The job of the stomach is to dissolve things quickly, so making this process slower can be challenging. One solution? Make a pill with some specifically designed polymers!
For example, a medicine called nifedipine is used to treat high blood pressure, which is great news for almost 1 billion people suffering from this disease worldwide. However, the bad news is that nifedipine does not usually have enough time to dissolve in the stomach. Fortunately, a polymer comes to the rescue. A polymer called poly(vinylpyrrolidone) and is used to boost the ability of nifedipine to dissolve in the stomach. Scientists mix the low solubility nifedipine with the poly(vinylpyrrolidone) to form a tablet. By dressing nifedipine in a cloak made of this polymer, the drug is then able to safely reach the bloodstream (Figure 3) . This is just one example of the many ways that macromolecules can have a positive impact on our health. So, the next secret to being healthy would not necessarily involve singing our hearts out to a popular Christmas song from the movie Love Actually, but might—actually—involve macromolecules.
Macromolecule: ↑ A very large molecule that contains thousands of atoms or more.
Polymer: ↑ A large molecule, or macromolecule, composed of many repeating units called monomers.
Monomer: ↑ A building block, or repeating unit, of a polymer.
Synthetic: ↑ Man-made from chemicals.
DNA: ↑ Material that carries the genetic information about how a living thing looks and functions.
Biocompatibility: ↑ The ability of a material to exist in the body without hurting the living tissue.
Solubility: ↑ The ability of a substance to mix into a liquid.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We would like to thank our mentors and advisors Dr. Paolo Decuzzi, Dr. Leanne Stokes, and Prof. Mark Searcey. This work was supported by the BBSRC Norwich Research Park Biosciences Doctoral Training Partnership (BB/M011216/1, 1794654) and the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 754490.
 ↑ Mülhaupt, R. 2014. Hermann Staudinger and the origin of macromolecular chemistry. Angew. Chem. Int. Ed. Engl. 43:1054–63. doi: 10.1002/anie.200330070
 ↑ Vandenberg, E. J. 2012. Contemporary Topics in Polymer Science. Vol. 5. New York, NY: Springer Science & Business Media.
 ↑ Langer, R., and Tirrell, D. A. 2004. Designing materials for biology and medicine. Nature 428:487. doi: 10.1038/nature02388
 ↑ Marsac, P. J., Konno, H., and Taylor, L. S. 2006. A comparison of the physical stability of amorphous felodipine and nifedipine systems. Pharm. Res. 23:2306. doi: 10.1007/s11095-006-9047-9